PD-L1 expression and its significance in advanced NSCLC: real-world experience from a tertiary care center

Autor: Sindhu Kilaru, Soumya Surath Panda, Lalatendu Moharana, Debahuti Mohapatra, Satya Sundar G. Mohapatra, Adyakinkar Panda, Spoorthy Kolluri, Suma Devaraj, Ghanashyam Biswas
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of the Egyptian National Cancer Institute, Vol 36, Iss 1, Pp 1-7 (2024)
Druh dokumentu: article
ISSN: 2589-0409
DOI: 10.1186/s43046-024-00207-5
Popis: Abstract Background Targeted therapies against programmed death ligand-1 (PD-L1) in non-small cell lung cancer (NSCLC) have revolutionized the management in recent years. There is paucity of data on the significance of PD-L1 expression in NSCLC from India. We aimed to study the prevalence of PD-L1 expression and its relation with different clinico-pathological parameters in advanced NSCLC from a tertiary care center in Eastern India. Methods All consecutive patients with advanced NSCLC diagnosed from January 2020 to December 2021 were prospectively evaluated for PD-L1 expression in formalin fixed-paraffin embedded tumor tissue specimens using immunohistochemistry analysis. A PD-L1 expression of
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