Combatting Malaysia's Dengue Outbreaks with Auto-Dissemination Mosquito Traps: A Hybrid Stochastic-Deterministic SIR Model

Autor: Jonathan Wells, David Greenhalgh, Yanfeng Liang, Itamar Megiddo, Wasi Ahmad Nazni, Teoh Guat-Ney, Han Lim Lee
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Communication in Biomathematical Sciences, Vol 6, Iss 2, Pp 169-188 (2023)
Druh dokumentu: article
ISSN: 2549-2896
DOI: 10.5614/cbms.2023.6.2.7
Popis: Classical mosquito control methods (e.g. chemical fogging) struggle to sustain long-term reductions in mosquito populations to combat vector-borne diseases like dengue. The Mosquito Home System (MHS) is an auto-dissemination mosquito trap, that kills mosquito larvae before they hatch into adult mosquitoes. A novel hybrid stochastic-deterministic model is presented, that successfully predicts the effect of deploying MHSs within high-rise flats in Selangor, Malaysia. Stochastic SIR (Susceptible-Infected-Recovered) equations (flats) are paired with an existing deterministic SIR model (wider Kuala Lumpur population). Model predictions provide excellent agreement with data from a 44 week MHS trial within the flats. The stochastic model is validated as a powerful tool for predicting short- and long-term impacts of deploying this style of trap within similar environments. Significant, sustainable reductions in mosquito populations are predicted when the MHS is active: with a mean of 9 (95% Uncertainty Range (UR): 1; 30) during the 44 week trial period, compared to 35 (95% UR: 1; 234) dengue cases with no MHSs. Long-term predictions for endemic equilibrium show MHSs significantly narrow the mosquito population distribution and reduce dengue prevalence: from a mean of 5 (95% UR: 0; 52) (no MHS), to 1 (95% UR: 0; 8) dengue cases annually (with MHS).
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