| Autor: |
S. Ja. Loginova, V. N. Shchukina, S. V. Borisevich |
| Jazyk: |
ruština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Антибиотики и Химиотерапия, Vol 63, Iss 11-12, Pp 3-7 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0235-2990 |
| Popis: |
Studies have shown that high-molecular inducers of interferon Larigan®, Ridostin®, and Rifastin cause «early» interferon production which amounts to maximum 3 hours after injection. Re-introduction of interferon inducers with an interval of 3 days does not cause the inhibition of interferon synthesis, i.e. refractoriness is not observed. Oral administration of a low molecular weight interferon inducer Arbidol® also stimulates the synthesis of endogenous interferon in the blood serum of rabbits, but in much lower concentrations. Reaferon® when administered intramuscularly to primates in therapeutically effective concentrations is detected in the serum of monkeys 6 hours after application. Reaferon® is not detected in the serum of monkeys after oral administration. It was also impossible to identify the drug after intramuscular administration in rabbits, even at high doses. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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