| Autor: |
Martin Peglow, Barbara A Niemeyer, Markus Hoth, Heiko Rieger |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
New Journal of Physics, Vol 15, Iss 5, p 055022 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1367-2630 |
| DOI: |
10.1088/1367-2630/15/5/055022 |
| Popis: |
To analyze the influence of Ca ^2+ microdomains on the global cytosolic Ca ^2+ concentration, we consider the polarization and activation of T-cells after the formation of an immunological synapse as a model system. For T-cell proliferation and activation, a high and robust Ca ^2+ signal lasting from minutes up to hours is needed. This raises the intriguing question of how T-cells overcome all those mechanisms which normally remove an increased Ca ^2+ level as fast as possible from the cytosol. With the help of theoretical models we predict that, after the formation of a local Ca ^2+ influx pathway via STIM1 and Orai1, mitochondria relocation toward and accumulation of plasma membrane Ca ^2+ ATPase and sarcoplasmic/ endoplasmic reticulum calcium ATPase pumps at the immunological synapse are sufficient to achieve a long-lasting increased global Ca ^2+ concentration. In addition, we also uncover new mechanisms to generate Ca ^2+ oscillations, which are important for efficient T-cell activation. Experimental tests and the implications of our predictions are discussed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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