Therapeutic effects of creatine supplementation in patients with type II diabetes

Autor: Aleksander Oskroba, Mateusz Pawlina, Aleksandra Orzechowska, Karolina Ziętara, Natalia Pawełczak, Karolina Raksa, Bartłomiej Zielonka, Ilona Kowalczyk, Piotr Pawłowski, Cezary Stawikowski
Jazyk: English<br />Spanish; Castilian<br />Polish<br />Russian<br />Ukrainian
Rok vydání: 2023
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 16, Iss 1 (2023)
Druh dokumentu: article
ISSN: 2391-8306
DOI: 10.12775/JEHS.2023.16.01.008
Popis: Background: Type 2 diabetes mellitus (T2DM) prevalence is disturbingly increasing all over the world. Clinicians and patients need new ways of improving T2DM therapy. Aim of this study: The aim of this study is to present the current scientific literature on the potential hypoglycemic effects of creatine in patients with type 2 diabetes. Material and methods: A systematic review of the scientific and medical literature from the PubMed and Google Scholar databases was carried out. This was achieved according to the keywords: type 2 diabetes and creatine supplementation. 25 items of literature were qualified for analysis. Results and conclusions: Creatine supplementation, when combined with physical activity, improves glycemic control in type 2 diabetic patients. Increased glucose transfer into muscle cells by type 4 glucose transporter (GLUT-4) translocation to the sarcolemma is one of the potential mechanisms explaining these hypoglycemic effects. Creatine has a big potential to become a nutritional therapy adjuvant for type 2 diabetes. However, in order to draw firm conclusions about the efficacy and safety of creatine as a diabetic intervention, larger, longer-term, controlled trials involving type 2 diabetes with variable disease severity and different pharmacological treatments are required.
Databáze: Directory of Open Access Journals