The importance of apoptosis for immune regulation in Chagas disease

Autor:	George A DosReis, Marcela F Lopes
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	apoptosis lymphocytes phagocytosis cytokines Trypanosoma cruzi Microbiology QR1-502 Infectious and parasitic diseases RC109-216
Zdroj:	Memorias do Instituto Oswaldo Cruz, Vol 104, Pp 259-262 (2009)
Druh dokumentu:	article
ISSN:	0074-0276 1678-8060
DOI:	10.1590/S0074-02762009000900033
Popis:	Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates the growth of T. cruzi inside host macrophages. In spite of progress made in this area, the importance of apoptosis in the pathogenesis of Chagas disease remains unclear. Here we review the evidence of apoptosis in mice and humans infected with T. cruzi. We also discuss the mechanisms by which apoptosis can influence underlying host responses and tissue damage during Chagas disease progression.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cf3c6713eb834120a504c89d2b3686a5 Zobrazit plný text záznamu View record in DOAJ