| Autor: |
Yuji Kawaguchi, Yuriko Hajika, Narumi Ashida, Maho Rinka, Chie Hamai, Koji Masumoto, Jun Sawa, Kenji Hamazaki, Yasuro Kumeda |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Metabolism Open, Vol 24, Iss , Pp 100318- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2589-9368 |
| DOI: |
10.1016/j.metop.2024.100318 |
| Popis: |
Aim/introduction: Early therapeutic interventions are necessary to reduce cardiovascular and renal composite endpoints in individuals with type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD). Clinical trials have shown that finerenone suppresses cardiovascular and renal composite endpoints by reducing the urinary albumin-to-creatinine ratio (UACR) and suppressing the decline in the Estimated Glomerular Filtration Rate (eGFR). However, the efficacy and safety of finerenone in real-world clinical practice remain unclear. This study aimed to evaluate the reduction in the UACR as an efficacy endpoint as well as changes in eGFR and serum potassium levels as safety endpoints before and after finerenone administration. Materials and methods: This retrospective observational study collected data from outpatients with T2DM and DKD upon initiation of finerenone treatment and 3 months after treatment. The primary efficacy endpoint was the change in the UACR from the start of finerenone treatment to after 3 months, while the primary safety endpoints were the changes in serum potassium levels and eGFR over the same period. Results: The mean UACR significantly decreased from 668.6 mg/gCr at the start of finerenone treatment to 367.8 mg/gCr after 3 months (p 0.05). Conclusions: In individuals with T2DM and DKD, finerenone treatment significantly reduced the UACR, with no post-treatment changes in potassium levels or eGFRs. Trial registration: This trial was registered with the University Hospital Medical Information Network Clinical Trial Registry (UMIN000054821). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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