METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

Autor: Lijun Wang, Jiaqi Wang, Pujiao Yu, Jingyi Feng, Gui-e Xu, Xuan Zhao, Tianhui Wang, H. Immo Lehmann, Guoping Li, Joost P. G. Sluijter, Junjie Xiao
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34434-y
Popis: The benefit of regular exercise on the heart has been well documented but the role of RNA m6A modification in exercise-induced cardiac remodelling remains largely unknown. In this study, the authors report that METTL14 plays an important role in RNA m6A modification in exercise-induced physiological cardiac hypertrophy.
Databáze: Directory of Open Access Journals