Splenic Rupture Secondary to Amyloidosis: A Case Report and Review of the Literature

Autor: Hisham F. Bahmad, Samantha Gogola, Lorena Burton, Ferial Alloush, Mike Cusnir, Michael Schwartz, Lydia Howard, Vathany Sriganeshan
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Hematology Reports, Vol 15, Iss 2, Pp 370-383 (2023)
Druh dokumentu: article
ISSN: 2038-8330
DOI: 10.3390/hematolrep15020038
Popis: Amyloidosis is a term describing the extracellular deposit of fibrils composed of subunits of several different normal serum proteins in various tissues. Amyloid light chain (AL) amyloidosis contains fibrils that are composed of fragments of monoclonal light chains. Many different disorders and conditions can lead to spontaneous splenic rupture, including AL amyloidosis. We present a case of a 64-year-old woman with spontaneous splenic rupture and hemorrhage. A final diagnosis of systemic amyloidosis secondary to plasma cell myeloma was made with infiltrative cardiomyopathy and possible diastolic congestive heart failure exacerbation. We also provide a narrative review of all documented cases of splenic rupture associated with amyloidosis from the year 2000 until January 2023, along with the main clinical findings and management strategies.
Databáze: Directory of Open Access Journals