| Autor: |
AN Mahamad Irfanulla Khan, CS Prashanth, N Srinath |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
AIMS Molecular Science, Vol 7, Iss 4, Pp 328-348 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2372-0301 |
| DOI: |
10.3934/molsci.2020016?viewType=HTML |
| Popis: |
Genetic studies in humans have demonstrated that Cleft lip with or without cleft palate (CL/P) have a diverse genetic background and probably environmental factors influencing these malformations. CL/P is one of the most common congenital birth defects in the craniofacial region with complex etiology involving multiple genetic factors, environmental factors and gene-environment interaction. Children born with these defects suffer from various difficulties such as difficulty in speech, hearing, feeding and other psychosocial problems, and their rehabilitation involves a multidisciplinary approach. The article describes the brief introduction of CL/P, epidemiology and general concepts, etiological factors, and the genes implicated in the etiology of nonsyndromic CL/P (NSCL/P) as suggested by different human genetic studies, animal models, and other expression studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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