| Autor: |
Chao-Yue Cui, Qian He, Qiu-Lin Jia, Cang Li, Chong Chen, Xiao-Ting Wu, Xiao-Jing Zhang, Zhuo-Yu Lin, Zi-Jian Zheng, Xiao-Ping Liao, Barry N. Kreiswirth, Ya-Hong Liu, Liang Chen, Jian Sun |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
mSystems, Vol 6, Iss 3 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2379-5077 |
| DOI: |
10.1128/mSystems.00050-21 |
| Popis: |
The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the clinical efficacy of tigecycline as a last-resort antibiotic to treat multidrug-resistant (MDR) Gram-negative bacterial infections. However, the molecular mechanisms leading to high-level tigecycline resistance remain elusive. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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