Biofilm growth and IL-8 & TNF-α-inducing properties of Candida albicans in the presence of oral gram-positive and gram-negative bacteria

Autor:	Radhika G. Bhardwaj, Arjuna Ellepolla, Hana Drobiova, Maribasappa Karched
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Candida albicans Polymicrobial biofilms qPCR Gram-positive bacteria Gram-negative bacteria Cytokines Microbiology QR1-502
Zdroj:	BMC Microbiology, Vol 20, Iss 1, Pp 1-11 (2020)
Druh dokumentu:	article
ISSN:	1471-2180
DOI:	10.1186/s12866-020-01834-3
Popis:	Abstract Background Interaction of C. albicans with oral bacteria is crucial for its persistence, but also plays a potential role in the infection process. In the oral cavity, it grows as part of dental plaque biofilms. Even though growth and interaction of C. albicans with certain bacterial species has been studied, little is known about its biofilm growth in vitro in the simultaneous presence of Gram-negative and Gram-positive bacteria. The aim was to evaluate the growth of C. albicans in polymicrobial biofilms comprising oral Gram-negative and Gram-positive bacteria. Further, we also aimed to assess the potential of C. albicans in the Candida-bacteria polymicrobial biofilm to elicit cytokine gene expression and cytokine production from human blood cells. Results C. albicans cell counts increased significantly up to 48 h in polymicrobial biofilms (p
Databáze:	Directory of Open Access Journals
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