| Autor: |
Morten Sandvik, Christopher O. Miles, Alistair L. Wilkins, Christiane Fæste |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Toxicon: X, Vol 6, Iss , Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1710 |
| DOI: |
10.1016/j.toxcx.2020.100031 |
| Popis: |
We have investigated the in vitro metabolism of pectenotoxin-2 (PTX-2) using primary hepatocytes from Wistar rats in suspension. Purified PTX-2 was rapidly metabolized. Two major and several minor oxidized PTX-2 metabolites were formed, none of which had retention times corresponding to PTX-1, -11, or −13. Hydrolysis products, such as PTX-2 seco acid, were not observed. Preliminary multi-stage LC-MS analyses indicated that the major hepatic PTX-2 metabolites resulted from the insertion of an oxygen atom at the positions C-19 to C-24, or at C-44. The rapid oxidative metabolism may explain the low oral toxicity of PTXs observed in vivo studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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