MOLECULAR DYNAMICS AND STRUCTURAL COMPARISON APPROACH TO UNDERSTANDING THE ROLE OF KNOTS IN PROTEINS

Autor: AGATA P. PERLINSKA, JOANNA M. MACNAR, JOANNA I. SULKOWSKA
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: TASK Quarterly, Vol 20, Iss 4 (2016)
Druh dokumentu: article
ISSN: 1428-6394
DOI: 10.17466/tq2016/20.4/h
Popis: The role of knots in proteins is still unclear. In this short review, we summarize the current knowledge about structural and dynamical differences between knotted and unknotted proteins. We show how the topological difference helps to distinguish the physical properties, characterize the biological activity or identify the biological function of knotted proteins. This knowledge can be used to correctly annotate protein family members and to identify new members.
Databáze: Directory of Open Access Journals