| Autor: |
Pia Dahlberg, Karl‐Jonas Axelsson, Steen M. Jensen, Gunilla Lundahl, Farzad Vahedi, Rosie Perkins, Lennart Gransberg, Lennart Bergfeldt |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Physiological Reports, Vol 10, Iss 21, Pp n/a-n/a (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2051-817X |
| DOI: |
10.14814/phy2.15487 |
| Popis: |
Abstract Hysteresis, a ubiquitous regulatory phenomenon, is a salient feature of the adaptation of ventricular repolarization duration to heart rate (HR) change. We therefore compared the QT interval adaptation to rapid HR increase in patients with the long QT syndrome type 1 (LQT1) versus healthy controls because LQT1 is caused by loss‐of‐function mutations affecting the repolarizing potassium channel current IKs, presumably an important player in QT hysteresis. The study was performed in an outpatient hospital setting. HR was increased in LQT1 patients and controls by administering an intravenous bolus of atropine (0.04 mg/kg body weight) for 30 s. RR and QT intervals were recorded by continuous Frank vectorcardiography. Atropine induced transient expected side effects but no adverse arrhythmias. There was no difference in HR response (RR intervals) to atropine between the groups. Although atropine‐induced ΔQT was 48% greater in 18 LQT1 patients than in 28 controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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