Pathomorphological changes in pulmonary vessels at different terms of lethal outcomes of patients with COVID-19

Autor: S. S. Todorov, V. Yu. Deribas, A. S. Kazmin, G. L. Reznikova, Yu. M. Makarenko, F. V. Polesovoy, S. S. Todorov (jr)
Jazyk: English<br />Russian
Rok vydání: 2021
Předmět:
Zdroj: Медицинский вестник Юга России, Vol 12, Iss 2, Pp 54-61 (2021)
Druh dokumentu: article
ISSN: 2219-8075
2618-7876
DOI: 10.21886/2219-8075-2021-12-2-54-61
Popis: Objective: to study the pathomorphological changes in the vessels of the lungs at different times of death in patients with COVID-19. Material and methods: autopsy protocols of 40 deaths from COVID-19 with histological, histochemical examination, and photoregistration. To determine the degree of pulmonary vascular lesions, the authors developed and applied a semi-quantitative assessment scale for the sign based on counting the affected lung vessels in 10 fields of view, expressed as a percentage: no sign – (0%), weak sign + (1-25%), moderate sign ++ (26-50%), expressed sign +++ (51-75%), highly expressed sign ++++ (76-100%). Results: during the first 14 days of the disease, stasis and swelling of individual endotheliocytes were noted in the vessels of the microvasculature. After 15-21 days of the development of COVID-19, signs of alterations in endothelial cells and microthrombosis were observed in microvessels. After 22-28 days of the disease, the phenomena of repair and hyperplasia of endothelial cells were detected. At different times of the development of the disease in the lung tissue, the phenomena of acute respiratory distress syndrome, interstitial pneumonia, and focal pneumofibrosis were observed. Conclusions: the authors believe that COVID-19 is associated with a progressive microvascular endotheliopathy in the lungs which is characterized by swelling, alteration, and later, by hyperplasia, and regeneration of endothelial cells in combination with microthrombosis. Destructive changes in the walls of the microvessels of the lungs have superficial character without the destruction of the reticular frame and basal membranes. Endotheliopathy, microthrombus formation of microvessels of the lungs, and interstitial pneumonia create a vicious circle of severe respiratory failure, which must be taken into account in the clinic to correct the treatment of patients with COVID-19.
Databáze: Directory of Open Access Journals
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