A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
| Autor: | Raquel Granell, John A Curtin, Sadia Haider, Negusse Tadesse Kitaba, Sara A Mathie, Lisa G Gregory, Laura L Yates, Mauro Tutino, Jenny Hankinson, Mauro Perretti, Judith M Vonk, Hasan S Arshad, Paul Cullinan, Sara Fontanella, Graham C Roberts, Gerard H Koppelman, Angela Simpson, Steve W Turner, Clare S Murray, Clare M Lloyd, John W Holloway, Adnan Custovic, on behalf of UNICORN and Breathing Together investigators |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | eLife, Vol 12 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2050-084X 37692801 |
| DOI: | 10.7554/eLife.84315 |
| Popis: | Background: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of ‘doctor-diagnosed asthma’, thereby diluting genetic signals by not considering asthma heterogeneity. The objective of our study was to identify genetic associates of childhood wheezing phenotypes. Methods: We conducted a novel multivariate GWAS meta-analysis of wheezing phenotypes jointly derived using unbiased analysis of data collected from birth to 18 years in 9568 individuals from five UK birth cohorts. Results: Forty-four independent SNPs were associated with early-onset persistent, 25 with pre-school remitting, 33 with mid-childhood remitting, and 32 with late-onset wheeze. We identified a novel locus on chr9q21.13 (close to annexin 1 [ANXA1], p |
| Databáze: | Directory of Open Access Journals |
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