Tumor-associated microbiome features of metastatic colorectal cancer and clinical implications

Autor: Ho Jung An, Mira A. Partha, HoJoon Lee, Billy T. Lau, Dmitri S. Pavlichin, Alison Almeda, Anna C. Hooker, Giwon Shin, Hanlee P. Ji
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Oncology, Vol 13 (2024)
Druh dokumentu: article
ISSN: 2234-943X
DOI: 10.3389/fonc.2023.1310054
Popis: BackgroundColon microbiome composition contributes to the pathogenesis of colorectal cancer (CRC) and prognosis. We analyzed 16S rRNA sequencing data from tumor samples of patients with metastatic CRC and determined the clinical implications.Materials and methodsWe enrolled 133 patients with metastatic CRC at St. Vincent Hospital in Korea. The V3-V4 regions of the 16S rRNA gene from the tumor DNA were amplified, sequenced on an Illumina MiSeq, and analyzed using the DADA2 package.ResultsAfter excluding samples that retained
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