The Influence of Female Reproductive Factors on Longevity: A Systematized Narrative Review of Epidemiological Studies

Autor: Christy Costanian PhD, Raymond Farah MSc, Ray Salameh BSc, Brad A. Meisner PhD, Sola Aoun Bahous MD, PhD, Abla M. Sibai PhD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Gerontology and Geriatric Medicine, Vol 8 (2022)
Druh dokumentu: article
ISSN: 2333-7214
23337214
DOI: 10.1177/23337214221138663
Popis: Purpose: This systematized review presents a synthesis of epidemiological studies that examine the association between female reproductive factors and longevity indicators. Methods: A comprehensive literature search was conducted using four bibliographic databases: OVID Medline, Web of Science, PubMed, and Google Scholar, including English language articles published until March 2022. Results from the search strategy yielded 306 articles, 37 of which were included for review based on eligibility criteria. Results were identified within the following nine themes: endogenous androgens and estrogens, age at first childbirth, age at last childbirth, parity, reproductive lifespan, menopause-related factors, hormone therapy use, age at menarche, and offspring gender. Results: Evidence that links reproductive factors and long lifespan is limited. Several female reproductive factors are shown to be significantly associated with longevity, yet findings remain inconclusive. The most consistent association was between parity (fertility and fecundity) and increased female lifespan. Age at first birth and parity were consistently associated with increased longevity. Associations between age at menarche and menopause, premature menopause, reproductive lifespan, offspring gender and longevity are inconclusive. Conclusion: There is not enough evidence to consider sex a longevity predictor. To understand the mechanisms that predict longevity outcomes, it is imperative to consider sex-specific within-population differences.
Databáze: Directory of Open Access Journals
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