| Autor: |
Yrvinn Campos-Vidal, Alejandro Zamilpa, Enrique Jiménez-Ferrer, Antonio Ruperto Jiménez-Aparicio, Brenda Hildeliza Camacho-Díaz, Gabriela Trejo-Tapia, Daniel Tapia-Maruri, Nayeli Monterrosas-Brisson, Maribel Herrera-Ruiz |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Plants, Vol 11, Iss 21, p 2951 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2223-7747 |
| DOI: |
10.3390/plants11212951 |
| Popis: |
Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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