Changing incidence of reported viral hepatitis in China from 2004 to 2016: an observational study

Autor: Ruihong Wu, Mingyuan Zhang, Hongqin Xu, Julia Uhanova, Robert Gish, Xiaoyu Wen, Qinglong Jin, Minuk Y Gerald, M H Nguyen, J Niu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMJ Open, Vol 9, Iss 8 (2019)
Druh dokumentu: article
ISSN: 2044-6055
DOI: 10.1136/bmjopen-2018-028248
Popis: ObjectiveChina’s national hepatitis burden is high. This study aims to provide a detailed national-level description of the reported incidence of viral hepatitis in China during 2004–2016.DesignObservational study.SettingData were obtained from China’s National Notifiable Disease Reporting System, and changing trends were estimated by joinpoint regression analysis.ParticipantsIn this system, 16 927 233 reported viral hepatitis cases occurring during 2004–2016 were identified.Primary outcome measureIncidence rates per 100 000 person-years and changing trends were calculated.ResultsThere were 16 927 233 new cases of viral hepatitis reported in China from 2004 to 2016. Hepatitis B (HBV) (n=13 543 137, 80.00%) and hepatitis C (HCV) (n=1 844 882, 10.90%) accounted for >90% of the cases. The overall annual percent change (APC) in reported cases of viral hepatitis and HBV were 0.3%(95% CI −2.0 to 0.8, p=0.6) and −0.2% (95% CI −1.6 to 1.2, p=0.8), respectively, showing a stable trend. HBV rates were highest in the 20–29 year old age group and lowest in younger individuals, likely resulting from the universal HBV vaccination. The reported incidence of HCV and hepatitis E (HEV) showed increasing trends; the APCs were 14.5% (95% CI 13.1 to 15.9, p
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