Study on the Frequent Expression of Rodgers and Chido, Red Blood Cell Antigens, in Iranian Healthy Population
| Autor: | Fatemeh Yari, Fatemeh Sabaghi, Nadia Bagheri, Maryam Zaman Vaziri, Maryam Sobhani, Zohreh Sharifi, Mahmoud Mahmoudian Shooshtari |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Cell Journal, Vol 11, Iss 1, Pp 62-62 (2009) |
| Druh dokumentu: | article |
| ISSN: | 2228-5806 2228-5814 |
| Popis: | Rodgers (Rg) and Chido (Ch) are blood-group antigens and they determine the fourthcomponentof human complement C4. Rodgers and Chido are associated with two C4isotypes (C4A and C4B). In addition to genotype determination, study on expression ofRg and Chido could be useful in disease studies.DNA was extracted from the whole blood of 60 normal individuals. Then, PCR amplificationof C4d gene fragment was followed by restriction digestion. This studydemonstrated that the frequency of Ch and Rg in Iranian healthy population was98.3 and 93.4 percent, respectively. Additionally, 6.6 percent of the studied populationshowed Chido-positive, Rodger-negative and 1.7 percent showed Rodger-positive,Chido-negative genotype. It may be concluded that upon receiving blood transfusion,6.6 and 1.7 percent of individuals could produce anti-Rg and anti-Ch antibodies, respectively. |
| Databáze: | Directory of Open Access Journals |
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