| Autor: |
Kyoko Yoshihara, Yasuhito Nannya, Ikuo Matsuda, Mami Samori, Nobuto Utsunomiya, Masaya Okada, Seiichi Hirota, Seishi Ogawa, Satoshi Yoshihara |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
eJHaem, Vol 3, Iss 1, Pp 211-214 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2688-6146 |
| DOI: |
10.1002/jha2.354 |
| Popis: |
Abstract A 64‐year‐old man with angioimmunoblastic T‐cell lymphoma (AITL) subsequently developed diffuse large B‐cell lymphoma (DLBCL) and myelodysplastic syndrome (MDS). Genomic profiling of AITL, DLBCL, and MDS samples revealed that the tumor cells from all samples shared common mutations in TET2 and DNMT3A. In addition, the IDH2 mutation was observed in AITL, and TP53 mutation was observed in DLBCL and MDS. These findings illustrate the clonal relationship between AITL and DLBCL in addition to AITL and MDS, with the latter being increasingly reported. The present findings strongly support the theory of multistep and multilineage tumorigenesis from a common founder clone. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text