Application of Continuous Positive Airway Pressure for Thoracic Respiratory Motion Management: An Assessment in a Magnetic Resonance Imaging–Guided Radiation Therapy Environment

Autor: Evan Liang, MD, Jennifer L. Dolan, PhD, Eric D. Morris, PhD, Jonathan Vono, RRT, Luisa F. Bazan, MD, Mei Lu, PhD, Carri K. Glide-Hurst, PhD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Advances in Radiation Oncology, Vol 7, Iss 3, Pp 100889- (2022)
Druh dokumentu: article
ISSN: 2452-1094
DOI: 10.1016/j.adro.2021.100889
Popis: Purpose: Patient tolerability of magnetic resonance (MR)–guided radiation treatment delivery is limited by the need for repeated deep inspiratory breath holds (DIBHs). This volunteer study assessed the feasibility of continuous positive airway pressure (CPAP) with and without DIBH for respiratory motion management during radiation treatment with an MR-linear accelerator (MR-linac). Methods and Materials: MR imaging safety was first addressed by placing the CPAP device in an MR-safe closet and configuring a tube circuit via waveguide to the magnet bore. Reproducibility and linearity of the final configuration were assessed. Six healthy volunteers underwent thoracic imaging in a 0.35T MR-linac, with one free breathing (FB) and 2 DIBH acquisitions being obtained at 5 pressures from 0 to 15 cm-H2O. Lung and heart volumes and positions were recorded; repeatability was assessed by comparing 2 consecutive DIBH scans. Blinded reviewers graded images for motion artifact using a 3-point grading scale. Participants completed comfort and perception surveys before and after imaging sessions. Results: Compared with FB alone, FB-10, FB-12, and FB-15 cm H2O significantly increased lung volumes (+23%, +34%, +44%; all P
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