Asymmetric Mannich Reaction: Synthesis of Novel Chiral 5-(substituted aryl)-1,3,4-Thiadiazole Derivatives with Anti-Plant-Virus Potency

Autor:	Bai Song, Zhu Yunying, Wu Qin
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	anti-plant-virus activity asymmetric mannich reaction chiral 1 3 4-thiadiazole derivatives Organic chemistry QD241-441
Zdroj:	Heterocyclic Communications, Vol 25, Iss 1, Pp 47-51 (2019)
Druh dokumentu:	article
ISSN:	2191-0197 09480544
DOI:	10.1515/hc-2019-0005
Popis:	A series of novel chiral 5-(substituted aryl)-1,3,4-thiadiazole derivatives was synthesized in an enantioselective three-component Mannich reaction using cinchona alkaloid squaramide catalyst with excellent enantioselectivities (up to >99% enantiomeric excess (ee)). The bioassay results showed that these derivatives possessed good to excellent activities against tobacco mosaic virus (TMV).
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f30227bdcb9d4f16a8ee09480544e184 Zobrazit plný text záznamu View record in DOAJ