| Autor: |
Cristiana Rodrigues, Paula Laranjeira, Aryane Pinho, Isabel Silva, Sandra Silva, Margarida Coucelo, Ana Catarina Oliveira, Ana Teresa Simões, Inês Damásio, Helena Matos Silva, Mafalda Urbano, Ana Bela Sarmento-Ribeiro, Catarina Geraldes, M. Rosário Domingues, Julia Almeida, Ignacio Criado, Alberto Orfao, Artur Paiva |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Frontiers in Oncology, Vol 14 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2024.1380648 |
| Popis: |
IntroductionIn monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer.MethodsHere, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease. Results and discussionCD20+ T cells were more represented within the CD8+ T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vβ 5.1 in CD4+ CD20+ T cells in CLL. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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