The current landscape of spatial biomarkers for prediction of response to immune checkpoint inhibition

Autor:	Hannah L. Williams, Ana Leni Frei, Thibaud Koessler, Martin D. Berger, Heather Dawson, Olivier Michielin, Inti Zlobec
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	npj Precision Oncology, Vol 8, Iss 1, Pp 1-18 (2024)
Druh dokumentu:	article
ISSN:	2397-768X
DOI:	10.1038/s41698-024-00671-1
Popis:	Abstract Enabling the examination of cell-cell relationships in tissue, spatially resolved omics technologies have revolutionised our perspectives on cancer biology. Clinically, the development of immune checkpoint inhibitors (ICI) has advanced cancer therapeutics. However, a major challenge of effective implementation is the identification of predictive biomarkers of response. In this review we examine the potential added predictive value of spatial biomarkers of response to ICI beyond current clinical benchmarks.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f2ef085cd2a340bbb4523c525e173237 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ