Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study

Autor: Stein Harald Johnsen, Bjarne K. Jacobsen, Sigrid K. Brækkan, John-Bjarne Hansen, Ellisiv B. Mathiesen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nutrition Journal, Vol 17, Iss 1, Pp 1-9 (2018)
Druh dokumentu: article
ISSN: 1475-2891
DOI: 10.1186/s12937-018-0364-8
Popis: Abstract Background Whether long-chain n–3 PUFAs of marine origin have an anti-atherogenic effect in the general population has hardly been studied. In this population-based study, we hypothesized that fatty fish and fish oil intake protect against development of novel atherosclerotic plaques and is associated with reduced plaque size. Methods We obtained questionnaire-based information on fish consumption and carotid ultrasonography from 3900 persons aged 45–74 years. The questionnaires were validated by measuring serum concentrations of PUFAs and triglycerides in a subgroup. At follow-up seven years later, 2983 (76%) went through a second ultrasound scanning. Logistic regression and general linear models were used to analyze the outcome (plaque presence and plaque area) as a function of fish consumption, including analyses stratified on fish oil supplements. Results At baseline, lean fish intake
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