| Autor: |
Santosh K. Yadav, Rakesh K. Gupta, Sheema Hashem, Sabah Nisar, Taha Azeem, Ajaz A. Bhat, Najeeb Syed, Ravindra K. Garg, Vimala Venkatesh, Madeeha Kamal, Khalid Fakhro, Michael P. Frenneaux, Mohammad Haris |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Brain, Behavior, & Immunity - Health, Vol 2, Iss , Pp 100039- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3546 |
| DOI: |
10.1016/j.bbih.2020.100039 |
| Popis: |
Introduction: Antiretroviral therapy (ART) is considered the most effective way to prevent perinatal transmission of human immunodeficiency virus (HIV). However, there is little knowledge about the effect of ART on the brain of HIV uninfected children born to HIV infected mothers (HUC). The current study evaluated the brain’s microstructural integrity, and cognitive function in HUC compared to healthy children born to normal mothers (CHNM) and HIV infected children born to HIV infected mothers (HIC) to investigate the effect of in-utero exposure of ART on cerebral gray and white matter. Materials and methods: Forty nine HIC, 12 HUC and 18 CHNM underwent neuropsychological (NP) assessment and a brain MRI. Diffusion tensor imaging (DTI) data was used to generate fractional anisotropy (FA) and mean diffusivity (MD) maps. Voxel wise comparison for FA and MD was performed between three groups using an analysis of covariance (ANCOVA) including age and sex as covariates, and correction for multiple comparisons (false discovery rate (FDR), p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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