| Autor: |
Egorova Anastasia, Gatiyatullina Alsu, Terenzhev Dmitriy, Belov Timur, Kalinnikova Tatiana |
| Jazyk: |
English<br />French |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
E3S Web of Conferences, Vol 254, p 09011 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2267-1242 |
| DOI: |
10.1051/e3sconf/202125409011 |
| Popis: |
The study of biological activity of extracts from roots and rhizomes of male fern Dryopteris filix-mas was carried out in experiments with soil nematode Caenorhabditis elegans. The toxicity of extracts of D. filix-mas roots and rhizomes obtained by different methods varied over a wide range. Crude extract of male fern roots and rhizomes in concentration range 62.5–250 µg/ml had a weak toxic action on C. elegans organism by inducing death of 26.0–43.3% nematodes. The toxicity of relatively high concentrations (500 and 250 µg/ml) of water-ethanolic extracts might be compared with such of crude extract in concentrations 62.5–250 µg/ml. Biological activity of filicinic acids ethers was found very high: concentrations of crude extract of D. filix-mas roots and rhizomes and concentrations of filicinic acids ethers with similar toxicity for C. elegans organism were 40-fold different. Substances isolated from D. filix-mas roots and rhizomes have nematicidal activity and may be used for development of drugs to treat helminthiasis of humans and animals. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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