Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells

Autor: Isaac Jardin, Jose J. Lopez, Jose Sanchez-Collado, Luis J. Gomez, Gines M. Salido, Juan A. Rosado
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cells, Vol 11, Iss 8, p 1332 (2022)
Druh dokumentu: article
ISSN: 2073-4409
12928267
DOI: 10.3390/cells11081332
Popis: Tumors are composed by a heterogeneous population of cells. Among them, a sub-population of cells, termed cancer stem cells, exhibit stemness features, such as self-renewal capabilities, disposition to differentiate to a more proliferative state, and chemotherapy resistance, processes that are all mediated by Ca2+. Ca2+ homeostasis is vital for several physiological processes, and alterations in the patterns of expressions of the proteins and molecules that modulate it have recently become a cancer hallmark. Store-operated Ca2+ entry is a major mechanism for Ca2+ entry from the extracellular medium in non-excitable cells that leads to increases in the cytosolic Ca2+ concentration required for several processes, including cancer stem cell properties. Here, we focus on the participation of STIM, Orai, and TRPC proteins, the store-operated Ca2+ entry key components, in cancer stem cell biology and tumorigenesis.
Databáze: Directory of Open Access Journals
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