The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination

Autor:	Hideo Tsubouchi
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Dmc1 homologous recombination meiosis Rad51 RecA homologs synaptonemal complex Microbiology QR1-502
Zdroj:	Biomolecules, Vol 13, Iss 4, p 662 (2023)
Druh dokumentu:	article
ISSN:	2218-273X
DOI:	10.3390/biom13040662
Popis:	Homologous recombination (HR) is essential for meiosis in most sexually reproducing organisms, where it is induced upon entry into meiotic prophase. Meiotic HR is conducted by the collaborative effort of proteins responsible for DNA double-strand break repair and those produced specifically during meiosis. The Hop2-Mnd1 complex was originally identified as a meiosis-specific factor that is indispensable for successful meiosis in budding yeast. Later, it was found that Hop2-Mnd1 is conserved from yeasts to humans, playing essential roles in meiosis. Accumulating evidence suggests that Hop2-Mnd1 promotes RecA-like recombinases towards homology search/strand exchange. This review summarizes studies on the mechanism of the Hop2-Mnd1 complex in promoting HR and beyond.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f2bbe79913fb4b93b158a5ce3de6caea Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.