Autor: |
Philipp A. Loehrer, Miriam H. A. Bopp, Haidar S. Dafsari, Sieglinde Seltenreich, Susanne Knake, Christopher Nimsky, Lars Timmermann, David J. Pedrosa, Marcus Belke |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024) |
Druh dokumentu: |
article |
ISSN: |
2373-8057 |
DOI: |
10.1038/s41531-024-00717-y |
Popis: |
Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) effectively treats motor and non-motor symptoms in advanced Parkinson’s disease (PD). As considerable interindividual variability of outcomes exists, neuroimaging-based biomarkers, including microstructural metrics, have been proposed to anticipate treatment response. In this prospective open-label study, we sought to detect microstructural properties of brain areas associated with short-term non-motor outcomes following STN-DBS. Thirty-seven PD patients underwent diffusion MRI and clinical assessments at preoperative baseline and 6-month follow-up. Whole brain voxel-wise analysis assessed associations between microstructural metrics and non-motor outcomes. Intact microstructure within specific areas, including the right insular cortex, right putamen, right cingulum, and bilateral corticospinal tract were associated with greater postoperative improvement of non-motor symptom burden. Furthermore, microstructural properties of distinct brain regions were associated with postoperative changes in sleep, attention/memory, urinary symptoms, and apathy. In conclusion, diffusion MRI could support preoperative patient counselling by identifying patients with above- or below-average non-motor responses. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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