Identification of hub genes in the crosstalk between type 2 diabetic nephropathy and obesity according to bioinformatics analysis

Autor:	Shaomin Shi, Ke Ding, Feng Chen, Mei Yang, Lihua Ni, Xiaoyan Wu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Diabetic nephropathy obesity differentially expressed genes hub genes bioinformatics Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981
Zdroj:	Adipocyte, Vol 13, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	21623945 2162-397X 2162-3945
DOI:	10.1080/21623945.2024.2423723
Popis:	Diabetic nephropathy (DN) and obesity bring a huge burden to society. Obesity plays a crucial role in the progression of type 2 DN, but the pathophysiology remains unclear. Thus, we aimed the explore the association between type 2 DN and obesity using bioinformatics method. The gene expression profiles of type 2 DN (GSE96804) and obesity (GSE94752) were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were screened with the thresholds defined as |log2FC| ≥1 and P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f29fc9cf90b342a58005a24d71fe96d9 Zobrazit plný text záznamu View record in DOAJ