| Autor: |
Hongxu CHEN, Liwei YUAN, Junxiong ZHANG, Wenxin WANG, Jiale LIU, Chunmei WANG, Jinghui SUN, Chengyi ZHANG, He LI, Jianguang CHEN |
| Jazyk: |
čínština |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Shipin gongye ke-ji, Vol 43, Iss 14, Pp 385-391 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1002-0306 |
| DOI: |
10.13386/j.issn1002-0306.2021100209 |
| Popis: |
Objective: To study thesedative, anti-anxiety and hypnotic effects of Schisandra chinensis vine stem lignans (SSL) and its underlying mechanism. Methods: One hundred and fifty ICR male mice were evenly and randomly divided into 5 groups, namely the blank control group, the SSL low-dose group (35 mg/kg), middle-dose group (70 mg/kg), and high-dose group (140 mg/kg), and diazepam positive control group (4 mg/kg). All treatments were administered intragastrically, 0.1 mL/10 g and once daily for 7 days. The autonomous activities of mice were used to observe the sedative effect, the elevated plus maze and elevated zero Maze were used to observe the anti-anxiety effect. The synergistic sleep test of pentobarbital sodium at subthreshold and threshold doses was used to observe the hypnotic effect. Enzyme-linked immunosorbent assay (ELISA) was used to detect the content of γ-aminobutyric acid (GABA) and glutamate (Glu) in mouse brain tissue. Results: In comparison to the blank control group, the numbers of standing and spontaneous activities of the mice was significantly reduced (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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