| Autor: |
Takeshi Yoshimoto, Kanta Tanaka, Junpei Koge, Satoshi Saito, Hiroshi Yamagami, Yuriko Nakaoku, Kunihiro Nishimura, Eriko Yamaguchi, Tetsuya Chiba, Daisuke Kawakami, Masayuki Shiozawa, Naruhiko Kamogawa, Tsuyoshi Ohta, Tetsu Satow, Manabu Inoue, Yorito Hattori, Kazuo Washida, Hiroharu Kataoka, Kazunori Toyoda, Masatoshi Koga, Masafumi Ihara |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Stroke: Vascular and Interventional Neurology, Vol 1, Iss S1 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2694-5746 |
| DOI: |
10.1161/SVIN.01.suppl_1.000009 |
| Popis: |
Introduction: The ring finger protein 213 gene (RNF213) has been identified as a susceptibility gene for moyamoya disease, and the p.R4810K polymorphism as a founder variant commonly found in East Asian patients. 1 A recent large case‐control study including over 46,958 Japanese subjects reported that the RNF213 p.R4810K variant was a strong risk factor for Japanese cerebral infarction: the variant was found in 5.2% of patients with non‐cardioembolic stroke and in 2.1% of healthy controls. 2 Mechanical thrombectomy (MT) is a standard treatment for acute ischemic stroke due to occlusion of the internal carotid artery and M1 segment of the middle cerebral artery, but in East Asians, about 15–25% of LVOs for which MT was performed were reportedly caused by intracranial atherosclerotic disease (ICAD). 3 RNF213 p.R4810K variant may be involved to some extent in ICAD‐related LVO of Asian patients undergoing MT. In this study, we aimed to investigate the impact of RNF213 p.R4810K variant on EVT for anterior circulation LVO stroke. Methods: Of the consecutive ischemic stroke patients from 2011 to 2021 seen in our institute, patients who underwent EVT for acute occlusion of the intracranial ICA or M1 segment of MCA and signed a consent form for RNF213 genotyping were included. Outcomes were instant re‐occlusion, final modified Thrombolysis in Cerebral Infarction (mTICI) ≥2b reperfusion, early re‐occlusion, and modified Rankin Scale (mRS) score 0–2 at 90 days. Instant re‐occlusion was defined as occurrence of re‐occlusion during the procedure, whereas early re‐occlusion as re‐occlusion detected on magnetic resonance angiography within 2 weeks after confirmation of successful reperfusion at the end of the procedure. 4 Results: Of the 277 patients (128 women [46.2%]; median age, 76 years) analyzed, 10 (3.6%) patients had the RNF213 p.R4810K variant. The variant carriers were younger (67 years vs. 76 years, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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