Bone mineral density and body composition in males with motor neuron disease: A study from teaching hospital in southern part of India

Autor: Basavaraj G Sooragonda, Sandeep Agarwal, Rohit Ninan Benjamin, A T Prabhakar, Ajith Sivadasan, Nitin Kapoor, Kripa E Cherian, Felix K Jebasingh, Sanjith Aaron, Nihal Thomas, Vivek Mathew, Hesarghatta S Asha, Thomas V Paul
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Annals of Indian Academy of Neurology, Vol 24, Iss 2, Pp 211-216 (2021)
Druh dokumentu: article
ISSN: 0972-2327
1998-3549
DOI: 10.4103/aian.AIAN_293_20
Popis: Background: Osteoporosis and sarcopenia are important aspects of motor neuron disease (MND). Individuals with amyotrophic lateral sclerosis (MND-ALS) have an increased risk of falls and fractures. Currently, the standard of care does not involve a routine assessment of bone mineral density (BMD) and body composition in these patients. We aimed to assess BMD, bone mineral parameters and body composition in men with MND and compared them with healthy controls. Methods: Consecutive males between 50 and 80 years of age diagnosed as MND-ALS by revised El Escorial criteria and able to walk unassisted attending Neurology outpatient clinic were recruited into the study. Age, gender and body mass index (BMI) matched healthy controls were recruited from the local community. BMD and body composition were assessed by dual-energy x-ray absorptiometry (DXA). Bone mineral parameters and bone turnover markers (BTMs) were also assessed in them. Results: A total of 30 subjects with MND-ALS and 33 controls were recruited. The mean age (years) was 59.2 in cases and 61.2 in controls. The mean BMD (g/cm2) between the two groups was similar; however, BTMs were significantly higher in the MND group (P < 0.05). Subjects with MND-ALS had significantly lower mean appendicular lean mass (ALM) (19.9 versus 22.4 kg; P = 0.007) and ALM corrected for BMI than the healthy control group (0.858 versus 0.934 kg/kg/m2; P = 0.034). Sarcopenic obesity (Percentage fat mass >27% + ALM/BMI
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