| Autor: |
Abdullahi Balarabe Nazifi, Abdulhakim Abubakar, Mohammed Garba Magaji, Musa Aliyu, Nuhu Mohammed Danjuma |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Bulletin of the National Research Centre, Vol 46, Iss 1, Pp 1-11 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2522-8307 |
| DOI: |
10.1186/s42269-022-00800-5 |
| Popis: |
Abstract Background Eragrostis tremula Hochst. ex Steud. (Poaceae) is used in ethno-medicine as a memory enhancer. Studies have shown that the whole plant possesses memory enhancing potentials and could be beneficial in the management of amnesia and cognitive deficit. Aim This study was aimed at investigating the actions of E. tremula extract on diazepam-induced amnesia in mice. Acute toxicity profiling was done as stated by the Organization for Economic Co-operation and Development (OECD 425). Oral doses of 125, 250 and 500 mg/kg of E. tremula extract were used for the diazepam-induced amnesia studies. Cognitive function was evaluated using elevated plus maze (EPM) and novel object recognition tests (NORT). The brain tissues were evaluated for the concentrations of malondialdehyde (MDA), reduced glutathione (GSH) and superoxide dismutase (SOD) using enzyme-linked immunosorbent assay kits. Results The oral median toxic dose of E. tremula extract was assessed to be > 5000 mg/kg in mice. The extract substantially (p |
| Databáze: |
Directory of Open Access Journals |
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