| Autor: |
Genevieve E Martin, Maelenn Gouillou, Anna C Hearps, Thomas A Angelovich, Allen C Cheng, Fiona Lynch, Wan-Jung Cheng, Geza Paukovics, Clovis S Palmer, Richard M Novak, Anthony Jaworowski, Alan L Landay, Suzanne M Crowe |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 8, Iss 1, p e55279 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0055279 |
| Popis: |
Aging is associated with immune dysfunction and the related development of conditions with an inflammatory pathogenesis. Some of these immune changes are also observed in HIV infection, but the interaction between immune changes with aging and HIV infection are unknown. Whilst sex differences in innate immunity are recognized, little research into innate immune aging has been performed on women.This cross-sectional study of HIV positive and negative women used whole blood flow cytometric analysis to characterize monocyte and CD8(+) T cell subsets. Plasma markers of innate immune activation were measured using standard ELISA-based assays.HIV positive women exhibited elevated plasma levels of the innate immune activation markers CXCL10 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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