| Autor: |
S. Akhtar, R. AlAnsari, B. Hasan, S. Hasan, A. Zayer, J. AlHaddad, M.A. Ansari, F.A. Khan, A. Ul-Hamid, F.Z. Henari, G. Roshan Deen |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Saudi Chemical Society, Vol 28, Iss 5, Pp 101917- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1319-6103 |
| DOI: |
10.1016/j.jscs.2024.101917 |
| Popis: |
In this study, silver nanoparticles (AgNPs) were synthesized by utilizing different volumes of silver nitrate (AgNO3) and a medicinally important protein, bovine serum albumin (BSA); subsequently, their anticancer and antibacterial activities were investigated. The volume of AgNO3 and BSA were varied to obtain physically and chemically stable NPs for better therapeutic effects. The synthesized BSA@AgNPs were characterized by spectroscopic and microscopic methods, such as FTIR, and UV–Vis spectroscopy, SEM/EDS, and TEM/SAED. The characterization results offer substantial proof for the successful preparation of non-aggregated stable BSA@AgNPs. The EDS analysis revealed the presence of Ag, C, and O, thus reaffirming the preparation of BSA-conjugated AgNPs. The anticancer efficacy of BSA@AgNPs was studied against colorectal (HCT-116) and HeLa cancerous cell lines. The anticancer results showed that the treatment of cancer cells with BSA@AgNPs decreased the number of cells compared with untreated cells. The NPs prepared with a moderate amount of BSA showed a better inhibiting property than the particles prepared with a high amount of BSA. The antibacterial activity of BSA@AgNPs was studied against gram-positive (S. aureus) and gram-negative (E. coli) bacteria. SEM and TEM analyses confirmed that S. aureus and E. coli cells were damaged upon exposure to BSA@AgNPs in the form of deep pits and cavities as opposed to untreated cells. The obtained results show that the green synthesized BSA@AgNPs could be used as potential anticancer and antibacterial drugs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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