Probable congenital transmission of reticuloendotheliosis virus caused by vaccination with contaminated vaccines.

Autor: Kai Wei, Zhenhong Sun, Shufen Zhu, Wenlong Guo, Pengcheng Sheng, Zunmin Wang, Changliang Zhao, Qingyou Zhao, Ruiliang Zhu
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: PLoS ONE, Vol 7, Iss 8, p e43422 (2012)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0043422
Popis: Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks and 478 tissue samples were tested by dot-blot hybridization, nested PCR, and IFA. The results suggested the outbreak of disease was most probably due to the vaccination of REV-contaminated MD-CVI988/Rispens vaccines and ND-LaSota+IB-H120 vaccines. Furthermore, the REV was probably transmitted to the commercial chickens through congenital transmission.
Databáze: Directory of Open Access Journals