Ceruloplasmin (2-D PAGE) Pattern and Copper Content in Serum and Brain of Alzheimer Disease Patients

Autor: Rosanna Squitti, Carlo C. Quattrocchi, Gloria Dal Forno, Piero Antuono, David R. Wekstein, Concetta R. Capo, Carlo Salustri, Paolo M. Rossini
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Zdroj: Biomarker Insights, Vol 1, Pp 205-213 (2006)
Druh dokumentu: article
ISSN: 1177-2719
Popis: A dysfunction in copper homeostasis seems to occur in Alzheimer's disease (AD). We previously evidenced that an excess of non-ceruloplasmin-copper (NCC) correlated with the main functional, anatomical as well as cerebrospinal markers of the disease. Aim of our study was to investigate ceruloplasmin isoforms as potential actors in this AD copper dysfunction. Our data show that AD patients have ceruloplasmin fragments of low molecular weight (
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