Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D

Autor: E. Nicholas Petersen, Hae-Won Chung, Arman Nayebosadri, Scott B. Hansen
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms13873
Popis: Mechanosensation by biological membranes can be relayed by mechanical tension to ion channels. Here the authors show that phospholipase D (PLD) is activated by mechanical disruption of lipid rafts which allows PLD to mix with its substrate in the lipid membrane, and propose a kinetic model of force transduction.
Databáze: Directory of Open Access Journals