Biometabolites of Tamarindus indica play a remarkable cardioprotective role as a functional food in doxorubicin-induced cardiotoxicity models

Autor:	Hashi Akter, Md. Mamunur Rashid, Md. Shahidul Islam, Md. Amjad Hossen, Md. Atiar Rahman, Reham M. Algheshairy, Mona S. Almujaydil, Hend F. Alharbi, Afnan M. Alnajeebi
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Tamarindus indica Cardioprotective activity Valsartan Angiotensin type II receptor I Molecular docking Histopathological examination Nutrition. Foods and food supply TX341-641
Zdroj:	Journal of Functional Foods, Vol 96, Iss , Pp 105212- (2022)
Druh dokumentu:	article
ISSN:	1756-4646
DOI:	10.1016/j.jff.2022.105212
Popis:	This research investigated the cardioprotective effects of Tamarindus indica extracts (TIEx) in doxorubicin (Dox)-induced cardiotoxicity model. TIEx was tested for phytochemical and antioxidative status followed by a randomized controlled intervention in Swiss albino models. The results were verified by in silico interactions of GC-MS characterized phytocompounds against AT1 (angiotensin II type 1) receptor antagonist complexed with PPARγ agonist. TIEx showed an excellent antioxidative effect and a significant (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f25c0fdd81f841d1875f4eda30134258 Zobrazit plný text záznamu Full Text from ScienceDirect View record in DOAJ