Early events following bovine leukaemia virus infection in calves with different alleles of the major histocompatibility complex DRB3 gene

Autor: Agustina Forletti, Claudia María Lützelschwab, Rosana Cepeda, Eduardo N. Esteban, Silvina Elena Gutiérrez
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Veterinary Research, Vol 51, Iss 1, Pp 1-12 (2020)
Druh dokumentu: article
ISSN: 1297-9716
80015387
DOI: 10.1186/s13567-019-0732-1
Popis: Abstract Cattle maintaining a low proviral load (LPL) status after bovine leukaemia virus (BLV) infection have been recognized as BLV controllers and non-transmitters to uninfected cattle in experimental and natural conditions. LPL has been associated with host genetics, mainly with the BoLA class II DRB3 gene. The aim of this work was to study the kinetics of BLV and the host response in Holstein calves carrying different BoLA-DRB3 alleles. Twenty BLV-free calves were inoculated with infected lymphocytes. Two calves were maintained uninfected as controls. Proviral load, total leukocyte and lymphocyte counts, anti-BLVgp51 titres and BLVp24 expression levels were determined in blood samples at various times post-inoculation. The viral load peaked at 30 days post-inoculation (dpi) in all animals. The viral load decreased steadily from seroconversion (38 dpi) to the end of the study (178 dpi) in calves carrying a resistance-associated allele (*0902), while it was maintained at elevated levels in calves with *1501 or neutral alleles after seroconversion. Leukocyte and lymphocyte counts and BLVp24 expression did not significantly differ between genetic groups. Animals with
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