Electrocardiographic changes during low-dose, short-term therapy of cutaneous leishmaniasis with the pentavalent antimonial meglumine
| Autor: | A.L.P. Ribeiro, J.B. Drummond, A.C. Volpini, A.C. Andrade, V.M.A. Passos |
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| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 32, Iss 3, Pp 297-301 (1999) |
| Druh dokumentu: | article |
| ISSN: | 1414-431X 0100-879X |
| DOI: | 10.1590/S0100-879X1999000300008 |
| Popis: | The pentavalent antimonial (Sb5+) meglumine is the drug of choice for the treatment of cutaneous leishmaniasis (CL) in Brazil. Although the cardiotoxicity of high-dose, long-term Sb5+ therapy is well known, the use of low-dose, short-term meglumine has been considered to be safe and relatively free from significant cardiac effects. In order to investigate the cardiotoxicity of low-dose, short-term therapy with meglumine in cutaneous leishmaniasis, 62 CL patients treated with meglumine were studied. A standard ECG was obtained before and immediately after the first cycle of treatment (15 mg Sb5+ kg-1 day-1). The electrocardiographic interpretation was carried out blindly by two investigators using the Minnesota Code. There were no significant differences in qualitative ECG variables before and after meglumine treatment. However, the corrected QT interval was clearly prolonged after antimonial therapy (420.0 vs 429.3 ms, P |
| Databáze: | Directory of Open Access Journals |
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