Moderate-to-severe ARDS: COVID-19 patients compared to influenza patients for ventilator parameters and mortality
| Autor: | Adel Maamar, Pauline Guillot, Vincent Joussellin, Flora Delamaire, Benoit Painvin, Anaëlle Bichon, Océane Bernard de la Jartre, Matteo Mauget, Mathieu Lesouhaitier, Jean Marc Tadié, Nicolas Terzi, Arnaud Gacouin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | ERJ Open Research, Vol 9, Iss 2 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2312-0541 23120541 |
| DOI: | 10.1183/23120541.00554-2022 |
| Popis: | Background This study aimed to compare ventilatory parameters recorded in the first days of acute respiratory distress syndrome (ARDS) and mortality at day 60 between coronavirus disease 2019 (COVID-19) and influenza ARDS patients with arterial oxygen tension (PaO2)/inspiratory oxygen fraction (FIO2) ≤150 mmHg. Methods We compared 244 COVID-19 ARDS patients with 106 influenza ARDS patients. Driving pressure, respiratory system compliance (Crs), ventilator ratio, corrected minute ventilation (V′Ecorr) and surrogate of mechanical power (index=(4×driving pressure)+respiratory rate) were calculated from day 1 to day 5 of ARDS. A propensity score analysis and a principal component analysis (PCA) were performed. Results On day 1 of ARDS, COVID-19 patients had significantly higher PaO2/FIO2 (median (interquartile range) 97 (79–129.2) versus 83 (62.2–114) mmHg; p=0.001), and lower driving pressure (13.0 (11.0–16.0) versus 14.0 (12.0–16.7) cmH2O; p=0.01), ventilatory ratio (2.08 (1.73–2.49 versus 2.52 (1.97–3.03); p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|