Synthesis of Benzo[4,5]thiazolo[2,3-c][1,2,4]triazole Derivatives via C-H Bond Functionalization of Disulfide Intermediates

Autor:	Luis G. Ardón-Muñoz, Jeanne L. Bolliger
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	heteroaromatics C-H bond functionalization oxidative cyclization Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 5, p 1464 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27051464
Popis:	Many nitrogen- and sulfur-containing heterocyclic compounds exhibit biological activity. Among these heterocycles are benzo[4,5]thiazolo[2,3-c][1,2,4]triazoles for which two main synthetic approaches exist. Here we report a new synthetic protocol that allows the preparation of these tricyclic compounds via the oxidation of a mercaptophenyl moiety to its corresponding disulfide. Subsequent C-H bond functionalization is thought to enable an intramolecular ring closure, thus forming the desired benzo[4,5]thiazolo[2,3-c][1,2,4]triazole. This method combines a high functional group tolerance with short reaction times and good to excellent yields.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/dcf245bffab84f888ec89e6f1b2192f2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.