| Autor: |
Rashmi Dubey, Ashish Kumar Tewari, Ved Prakash Singh, Praveen Singh, Jawahar Singh Dangi, Carmen Puerta, Pedro Valerga, Rajni Kant |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
The Scientific World Journal, Vol 2013 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1537-744X |
| DOI: |
10.1155/2013/309710 |
| Popis: |
Two conformational polymorphs of novel 2-[2-(3-cyano-4,6-dimethyl-2-oxo-2H-pyridin-1-yl)-ethoxy]-4,6-dimethyl nicotinonitrile have been developed. The crystal structure of both polymorphs (1a and 1b) seems to be stabilized by weak interactions. A difference was observed in the packing of both polymorphs. Polymorph 1b has a better binding affinity with the cyclooxygenase (COX-2) receptor than the standard (Nimesulide). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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