| Autor: |
Alireza Shafiee-Kandjani, Majid Khalili, Ayyoub Malek, Sara Farhang, Younes Ranjbari, Yeganeh Khalili |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Phytomedicine Plus, Vol 3, Iss 2, Pp 100430- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0313 |
| DOI: |
10.1016/j.phyplu.2023.100430 |
| Popis: |
Background: Depression is one of the most common psychiatric disorders in today's society. The therapeutic effects of Lavandula angustifolia Mill. (Lamiaceae) (L. angustifolia) and Dracocephalum ruyschiana L. (Lamiaceae) (D. ruyschiana) have been demonstrated in the treatment of several disorders. Objectives: The present study aimed to evaluate the therapeutic effect of L. angustifolia and D. ruyschiana extracts on patients with mild to moderate depression under treatment with sertraline. Methods: This study was experimental with a pretest-posttest control group design. Seventy individuals with major depressive disorder were randomly allocated into two groups. The first group received a dose of 100 mg sertraline tablet per day with placebo syrup three times a day. The second group was treated with the same dose of sertraline plus the herbal syrup containing two units of the extract of L. angustifolia and one unit of the D. ruyschiana three times a day. The unit dose was the same as defined in traditional medicine. Data were collected using the Structured Clinical Interview for DSM-IV (SCID-IV) and Beck Depression Inventory (BDI) and analyzed using appropriate statistical methods. Results: The mean scores for depression by BDI in the two groups were not significantly different before the intervention (P > 0.05). Six weeks after the intervention the mean scores of depression in the experimental group were significantly lower than in the control group (P = 0.02). Conclusions: Simultaneous use of L. angustifolia and D. ruyschiana extracts alongside sertraline has beneficial effects in decreasing depression and confers a promising herbal medication in treating such patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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